One of Thutmose III's senior officers and much favored by him, Yamu-nedjeh accompanied the king on his campaigns in Western Asia and crossed the Euphrates with him. In civilian life Yamu-nedjeh was responsible for supervising the erection of three pairs of obelisks for the king, two at Karnak and one at Heliopolis. He was honored by having his statue set up in the king's mortuary temple.